2,232 research outputs found

    Blending Learning: The Evolution of Online and Face-to-Face Education from 20082015

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    In 2008, iNACOL produced a series of papers documenting promising practices identified throughout the field of K–12 online learning. Since then, we have witnessed a tremendous acceleration of transformative policy and practice driving personalized learning in the K–12 education space. State, district, school, and classroom leaders recognize that the ultimate potential for blended and online learning lies in the opportunity to transform the education system and enable higher levels of learning through competency-based approaches.iNACOL's core work adds significant value to the field by providing a powerful practitioner voice in policy advocacy, communications, and in the creation of resources and best practices to enable transformational change in K–12 education.We worked with leaders throughout the field to update these resources for a new generation of pioneers working towards the creation of student-centered learning environments.This refreshed series, Promising Practices in Blended and Online Learning, explores some of the approaches developed by practitioners and policymakers in response to key issues in K–12 education, including:Blended Learning: The Evolution of Online and Face-to-Face Education from 2008-2015;Using Blended and Online Learning for Credit Recovery and At-Risk Students;Oversight and Management of Blended and Online Programs: Ensuring Quality and Accountability; andFunding and Legislation for Blended and Online Education.Personalized learning environments provide the very best educational opportunities and personalized pathways for all students, with highly qualified teachers delivering world-class instruction using innovative digital resources and content. Through this series of white papers, we are pleased to share the promising practices in K–12 blended, online, and competency education transforming teaching and learning today

    Between “Voluntary Migrants” and War Refugees: The Health of the Shan Burmese Migrant Workers in Northern Thailand

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    The Shan are a large migrant group from Burma (Myanmar) found within Thailand. While some Shan migrate to escape the civil war within Burma, others migrate for economic opportunity. Despite the size of this population, little is known about their health. Our study highlights the need for expanded access to primary care among this Shan population. Despite the arduous and trying journeys of these Shan migrants, they do not display the level of health sometimes attributed to health selection among immigrant groups

    Dss1 is a 26S proteasome ubiquitin receptor

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    The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome. The proteasome subunits Rpn10 and Rpn13 are known to bind ubiquitin, but genetic and biochemical data suggest the existence of at least one other substrate receptor. Here, we show that the phylogenetically conserved proteasome subunit Dss1 (Sem1) binds ubiquitin chains linked by K63 and K48. Atomic resolution data show that Dss1 is disordered and binds ubiquitin by binding sites characterized by acidic and hydrophobic residues. The complementary binding region in ubiquitin is composed of a hydrophobic patch formed by I13, I44, and L69 flanked by two basic regions. Mutations in the ubiquitin-binding site of Dss1 cause growth defects and accumulation of ubiquitylated proteins

    Finite-Control-Set Model Predictive Control for Low-Voltage-Ride-Through Enhancement of PMSG Based Wind Energy Grid Connection Systems

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    Grid faults are found to be one of the major issues in renewable energy systems, particularly in wind energy conversion systems (WECS) connected to the grid via back-to-back (BTB) converters. Under such faulty grid conditions, the system requires an effective regulation of the active (P) and reactive (Q) power to accomplish low voltage ride through (LVRT) operation in accordance with the grid codes. In this paper, an improved finite-control-set model predictive control (FCS-MPC) scheme is proposed for a PMSG based WECS to achieve LVRT ability under symmetrical and asymmetrical grid faults, including mitigation of DC-link voltage fluctuation. With proposed predictive control, optimized switching states for cost function minimization with weighing factor (WF) selection guidelines are established for robust BTB converter control and reduced cross-coupling amid P and Q during transient conditions. Besides, grid voltage support is provided by grid side inverter control to inject reactive power during voltage dips. The effectiveness of the FCS-MPC method is compared with the conventional proportional-integral (PI) controller in case of symmetrical and asymmetrical grid faults. The simulation and experimental results endorse the superiority of the developed FCS-MPC scheme to diminish the fault effect quickly with lower overshoot and better damping performance than the traditional controller

    The Psychosocial Health of Shan Children in Northwest Thailand

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    We administered the Strengths and Difficulties Questionnaire (SDQ) to 51 Shan refugee children from Burma who are living in northern Thailand, and collected life histories from 11 of their families. Of the sample, 63% of the children were stateless, and none were Thai citizens. About 30% of the children had normal peer relationship subscores—a number well below Thai norms after correcting for multiple comparisons (p < .001). However, their overall functioning was not different from the Thai population as a whole

    Isolation and characterization of new genetic types of Toxoplasma gondii and prevalence of Trichinella murrelli from black bear (Ursus americanus)

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    Black bears (Ursus americanus) are hosts for two important zoonotic parasites, Toxoplasma gondii and Trichinella spp. and bears are hunted for human consumption in the USA. Little is known of the genetic diversity of T. gondii circulating in wildlife. In the present study, antibodies to T. gondii were found in juice from tongues of 17 (25.7%) of 66 wild black bear from Maryland during the hunting season of 2010 and 2011. Antibodies to T. gondii were assessed by the modified agglutination test. Tongues of 17 seropositive bears were bioassayed in mice and viable T. gondii was isolated from three samples. These three T. gondii isolates (TgBbMd1-3) were further propagated in cell culture and DNA isolated from culture-derived tachyzoites was characterized using 11 PCR-RFLP markers (SAG1, 5′ - and 3′ -SAG2, alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1 and Apico). Results revealed three genotypes. TgBbMd1 is a Type 12 strain (ToxoDB PCR-RFLP genotype #4) and TgBbMd2 is ToxoDB PCR- RFLP genotype #216, and TgBbMd3 is a Type II clonal strain (ToxoDB PCR-RFLP genotype #1). The isolate TgBbMd2 was highly virulent for outbred Swiss Webster mice; all infected mice died of acute toxoplasmosis. Results indicate that mouse virulent strains of T. gondii are circulating in wildlife in the USA. These 66 tongues in addition to tongues collected during hunts in previous years were further investigated for the presence of muscle larvae of Trichinella spp. Tongues from 40 bears in 2005, 41 in 2006, 51 in 2007, 56 in 2008, 68 in 2009, 67 in 2010, and 66 in 2011 were subjected to digestion with pepsin/HCl and microscopic examination. Two bears were infected with Trichinella spp.; one in 2008 and one in 2009. Genotyping of collected muscle larvae revealed that the infecting species in both cases was Trichinella murrelli
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